In the consolation bracket, Milosz Gudzowski defeated Stony Brook's Tal Meir, 6-2, 6-1 to move into the consolation quarterfinals.
In other action, the 14-seed doubles pair of Murphy and Wai fell in an 8-6 match to Princeton, while the duo of Rowan Reynolds and Chris Lawler fell to Martin Wetzel and Cliff Nyugen from Harvard, 8-3 after winning a tight 9-8(6) match against Virginia Tech.
Matt Feldman dropped a second-round match to Penn State's No. 6 seed Malcolm Scatliffe, 6-2, 6-4.
Murphy will face Army's John Houghton in the third round, after Houghton defeated Harvard's Chris Chiou in three sets after dropping the first. Wai will compete against No. 9 seed Soren Spanner from Virginia Tech.